Close proximity of immune and tumor cells underlies response to anti-PD-1 based therapies in metastatic melanoma patients

Close proximity of immune and tumor cells underlies response to anti-PD-1 based therapies in metastatic melanoma patients

Immune checkpoint blockade has greatly improved the clinical outcomes of many patients with metastatic melanoma, however, almost half do not respond. Whether the interspatial distribution of immune and tumor cells predicts response to anti-PD-1-based therapies and patient outcomes in any cancer, inc...

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Bibliographic Details
Main Authors: Tuba N. Gide, Ines P. Silva, Camelia Quek, Tasnia Ahmed, Alexander M. Menzies, Matteo S. Carlino, Robyn P.M. Saw, John F. Thompson, Marcel Batten, Georgina V. Long, Richard A. Scolyer, James S. Wilmott
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
spatial distribution
multiplex immunofluorescence
tumor-infiltrating lymphocytes
melanoma
anti-pd-1
anti-ctla-4
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1659093

Internet

http://dx.doi.org/10.1080/2162402X.2019.1659093

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