Ultrasound‐Triggered Delivery of Iproplatin from Microbubble‐Conjugated Liposomes

Ultrasound‐Triggered Delivery of Iproplatin from Microbubble‐Conjugated Liposomes

Abstract The PtIV prodrug iproplatin has been actively loaded into liposomes using a calcium acetate gradient, achieving a 3‐fold enhancement in drug concentration compared to passive loading strategies. A strain‐promoted cycloaddition reaction (azide‐ dibenzocyclooctyne) was used to attach iproplat...

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Bibliographic Details
Main Authors: Dr. Richard Browning, Nia Thomas, Laura K. Marsh, Dr. Louise R. Tear, Dr. Joshua Owen, Prof. Dr. Eleanor Stride, Dr. Nicola J. Farrer
Format: Article
Language:English
Published: Wiley-VCH 2021-12-01
Series:ChemistryOpen
Subjects:
cancer
drug delivery
iproplatin
liposome
ultrasound
Online Access:https://doi.org/10.1002/open.202100222

Internet

https://doi.org/10.1002/open.202100222

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