Structural Refinement of 2,4-Thiazolidinedione Derivatives as New Anticancer Agents Able to Modulate the BAG3 Protein

Structural Refinement of 2,4-Thiazolidinedione Derivatives as New Anticancer Agents Able to Modulate the BAG3 Protein

The multidomain BAG3 protein is a member of the BAG (Bcl-2-associated athanogene) family of co-chaperones, involved in a wide range of protein–protein interactions crucial for many key cellular pathways, including autophagy, cytoskeletal dynamics, and apoptosis. Basal expression of BAG3 is elevated...

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Bibliographic Details
Main Authors: Dafne Ruggiero, Stefania Terracciano, Gianluigi Lauro, Michela Pecoraro, Silvia Franceschelli, Giuseppe Bifulco, Ines Bruno
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
BAG3 protein
chaperones
cancer
virtual screening
2,4-thiazolidinedione scaffold
BAG domain modulators
Online Access:https://www.mdpi.com/1420-3049/27/3/665

Internet

https://www.mdpi.com/1420-3049/27/3/665

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