Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis

Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis

ABSTRACT Tuberculosis (TB), which is caused by the single pathogenic bacterium, Mycobacterium tuberculosis, is among the top 10 lethal diseases worldwide. This situation has been exacerbated by the increasing number of cases of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-T...

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Bibliographic Details
Main Authors: Siwei Mo, Jiubiao Guo, Taosheng Ye, Ximeng Zhang, Jiang Zeng, Yuzhong Xu, Bin Peng, Youchao Dai, Wei Xiao, Peize Zhang, Guofang Deng, Dechang Xu, Xiaoru Long, Yi Cai, Xinchun Chen
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
Mycobacterium tuberculosis
HRH1
NOX2
p38MAPK
ROS
Online Access:https://journals.asm.org/doi/10.1128/mbio.02004-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02004-22

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