Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?

Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?

The immune system plays a critical role in bone homeostasis and, consequently, in the pathophysiology of postmenopausal osteoporosis (OP) since estrogen deficiency induces the inflammasome and increases production of pro-inflammatory cytokines, such as IL-1β and IL-18. NLRP3 inflammasome complex gen...

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Bibliographic Details
Main Authors: Werbson Lima Guaraná, Camilla Albertina Dantas Lima, Alexandre Domingues Barbosa, Sergio Crovella, Paula Sandrin-Garcia
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Genes
Subjects:
osteoporosis
NLRP3
inflammasome
single-nucleotide variants
bone mineral density
vitamin D
Online Access:https://www.mdpi.com/2073-4425/13/12/2271

Internet

https://www.mdpi.com/2073-4425/13/12/2271

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