ATM depletion induces proteasomal degradation of FANCD2 and sensitizes neuroblastoma cells to PARP inhibitors

ATM depletion induces proteasomal degradation of FANCD2 and sensitizes neuroblastoma cells to PARP inhibitors

Abstract Background Genomic alterations, including loss of function in chromosome band 11q22-23, are frequently observed in neuroblastoma, which is the most common extracranial childhood tumour. In neuroblastoma, ATM, a DNA damage response-associated gene located on 11q22-23, has been linked to tumo...

Full description

Bibliographic Details
Main Authors: Sultana Parvin, Jesmin Akter, Hisanori Takenobu, Yutaka Katai, Shunpei Satoh, Ryu Okada, Masayuki Haruta, Kyosuke Mukae, Tomoko Wada, Miki Ohira, Kiyohiro Ando, Takehiko Kamijo
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Cancer
Subjects:
Neuroblastoma
ATM
FANCD2
ATR
RAD51
CRISPR/Cas9
Online Access:https://doi.org/10.1186/s12885-023-10772-y

Internet

https://doi.org/10.1186/s12885-023-10772-y

Similar Items