Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method

Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method

Introduction: Usnic acid (UA) and barbatic acid (BA), two typical dibenzofurans and depsides in lichen, have a wide range of pharmacological activities and hepatotoxicity concerns. This study aimed to clarify the metabolic pathway of UA and BA and illuminate the relationship between metabolism and t...

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Bibliographic Details
Main Authors: Hanxue Wang, Min Xuan, Juanjuan Diao, Nan Xu, Manlin Li, Cheng Huang, Changhong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
usnic acid
barbatic acid
metabolism
metabolic pathway
detoxification
UPLC/ESI-QTOF-MS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1207928/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1207928/full

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