Mechanically sensitive HSF1 is a key regulator of left-right symmetry breaking in zebrafish embryos

Mechanically sensitive HSF1 is a key regulator of left-right symmetry breaking in zebrafish embryos

Summary: The left-right symmetry breaking of vertebrate embryos requires nodal flow. However, the molecular mechanisms that mediate the asymmetric gene expression regulation under nodal flow remain elusive. Here, we report that heat shock factor 1 (HSF1) is asymmetrically activated in the Kupffer’s...

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Bibliographic Details
Main Authors: Jing Du, Shu-Kai Li, Liu-Yuan Guan, Zheng Guo, Jiang-Fan Yin, Li Gao, Toru Kawanishi, Atsuko Shimada, Qiu-Ping Zhang, Li-Sha Zheng, Yi-Yao Liu, Xi-Qiao Feng, Lin Zhao, Dong-Yan Chen, Hiroyuki Takeda, Yu-Bo Fan
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Developmental biology
Embryology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223019417

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223019417

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