Neuroglobin overexpression inhibits oxygen–glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons

Neuroglobin overexpression inhibits oxygen–glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons

Neuroglobin (Ngb) is an endogenous neuroprotective molecule against hypoxic/ischemic brain injury, but the underlying mechanisms remain largely undefined. Our recent study revealed that Ngb can bind to voltage-dependent anion channel (VDAC), a regulator of mitochondria permeability transition (MPT)....

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Bibliographic Details
Main Authors: Zhanyang Yu, Ning Liu, Yadan Li, Jianfeng Xu, Xiaoying Wang
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Neurobiology of Disease
Subjects:
Neuroglobin
Oxygen/glucose deprivation
Mitochondria permeability transition pore (mPTP)
NAD+ release
Mitochondria swelling
Cytochrome c
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001290

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http://www.sciencedirect.com/science/article/pii/S0969996113001290

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