Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates
The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells. The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2, resulting in conversion of Bcl-2 from a survival to killer. As Bcl-2 is overexpressed in various cancers preventing them f...
| Автори: | , , , , , , , , , , , |
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| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Elsevier
2024-03-01
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| Серія: | Acta Pharmaceutica Sinica B |
| Предмети: | |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S2211383523004392 |