Structural dynamics of HIV-1 envelope Gp120 outer domain with V3 loop.

BACKGROUND: The net charge of the hypervariable V3 loop on the HIV-1 envelope gp120 outer domain plays a key role in modulating viral phenotype. However, the molecular mechanisms underlying the modulation remain poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: By combining computational and experi...

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Bibliographic Details
Main Authors: Masaru Yokoyama, Satoshi Naganawa, Kazuhisa Yoshimura, Shuzo Matsushita, Hironori Sato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3356331?pdf=render