Molecular and Cellular Effects of Chemical Chaperone—TUDCA on ER-Stressed NHAC-kn Human Articular Chondrocytes Cultured in Normoxic and Hypoxic Conditions

Molecular and Cellular Effects of Chemical Chaperone—TUDCA on ER-Stressed NHAC-kn Human Articular Chondrocytes Cultured in Normoxic and Hypoxic Conditions

Osteoarthritis (OA) is considered one of the most common arthritic diseases characterized by progressive degradation and abnormal remodeling of articular cartilage. Potential therapeutics for OA aim at restoring proper chondrocyte functioning and inhibiting apoptosis. Previous studies have demonstra...

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Bibliographic Details
Main Authors: Magdalena Kusaczuk, Monika Naumowicz, Rafał Krętowski, Bartosz Cukierman, Marzanna Cechowska-Pasko
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
chondrocytes
ER stress
inflammation
tauroursodeoxycholate
osteoarthritis
Online Access:https://www.mdpi.com/1420-3049/26/4/878

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https://www.mdpi.com/1420-3049/26/4/878

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