Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst

Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting joints with a hallmark of autoantibody production. Mannan-enhanced collagen type II (COL2) antibody induced arthritis (mCAIA) in neutrophil cytosolic factor 1(Ncf1) mutation mouse is a chronic disease model imitating RA in...

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Bibliographic Details
Main Authors: Peibin Liang, Yanpeng Li, Rui Xu, Kutty Selva Nandakumar, Roma Stawikowska, Gregg B. Fields, Rikard Holmdahl
Format: Article
Language:English
Published: Springer 2022-05-01
Series:Molecular Biomedicine
Subjects:
Rheumatoid arthritis
Anti-COL2 antibody
Collagen type II induced arthritis
Neutrophil cytosolic factor 1
Chronic phase
Online Access:https://doi.org/10.1186/s43556-022-00076-1

Internet

https://doi.org/10.1186/s43556-022-00076-1

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