IGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in MDA-MB-231 metastatic breast cancer cells

IGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in MDA-MB-231 metastatic breast cancer cells

In the context of breast cancer metastasis study, we have shown in an in vitro model of cell migration that IGDQ-exposing (IsoLeu-Gly-Asp-Glutamine type I Fibronectin motif) monolayers (SAMs) on gold sustain the adhesion of breast cancer MDA-MB-231 cells by triggering Focal Adhesion Kinase and integ...

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Bibliographic Details
Main Authors: Sophie Ayama-Canden, Rodolfo Tondo, Liliana Piñeros, Noëlle Ninane, Catherine Demazy, Marc Dieu, Antoine Fattaccioli, Tijani Tabarrant, Stéphane Lucas, Davide Bonifazi, Carine Michiels
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Breast cancer
TNBC
Cell migration
Motogenic IGDQ motif
Fibronectin type I
Integrin alpha 5
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000434

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http://www.sciencedirect.com/science/article/pii/S1476558622000434

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