Development and application of an uncapped mRNA platform

Development and application of an uncapped mRNA platform

Background A novel uncapped mRNA platform was developed.Methods Five lipid nanoparticle (LNP)-encapsulated mRNA constructs were made to evaluate several aspects of our platform, including transfection efficiency and durability in vitro and in vivo and the activation of humoral and cellular immunity...

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Bibliographic Details
Main Authors: Xiaodi Zheng, Biao Liu, Peng Ni, Linkang Cai, Xiaotai Shi, Zonghuang Ke, Siqi Zhang, Bing Hu, Binfeng Yang, Yiyan Xu, Wei Long, Zhizheng Fang, Yang Wang, Wen Zhang, Yan Xu, Zhong Wang, Kai Pan, Kangping Zhou, Hanming Wang, Hui Geng, Han Hu, Binlei Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Annals of Medicine
Subjects:
Uncapped mRNA
LNP
Omicron strain neutralization
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2024.2437046

Internet

https://www.tandfonline.com/doi/10.1080/07853890.2024.2437046

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