Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and chronic traumatic encephalopathy (CTE). Although defects in nucleocytoplasmic transport (NCT) is reported...

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Bibliographic Details
Main Authors: Eric N Anderson, Andrés A Morera, Sukhleen Kour, Jonathan D Cherry, Nandini Ramesh, Amanda Gleixner, Jacob C Schwartz, Christopher Ebmeier, William Old, Christopher J Donnelly, Jeffrey P Cheng, Anthony E Kline, Julia Kofler, Thor D Stein, Udai Bhan Pandey
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
neurodegeneration
amyotrophic lateral sclerosis
chronic traumatic encephalopathy
TDP-43
Online Access:https://elifesciences.org/articles/67587

Internet

https://elifesciences.org/articles/67587

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