Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syn...

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Bibliographic Details
Main Authors: Andrea M. Kaminski, Percy P. Tumbale, Matthew J. Schellenberg, R. Scott Williams, Jason G. Williams, Thomas A. Kunkel, Lars C. Pedersen, Katarzyna Bebenek
Format: Article
Language:English
Published: Nature Portfolio 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05024-8

Internet

https://doi.org/10.1038/s41467-018-05024-8

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