Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis
DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syn...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05024-8 |
| _version_ | 1818433598537072640 |
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| author | Andrea M. Kaminski Percy P. Tumbale Matthew J. Schellenberg R. Scott Williams Jason G. Williams Thomas A. Kunkel Lars C. Pedersen Katarzyna Bebenek |
| author_facet | Andrea M. Kaminski Percy P. Tumbale Matthew J. Schellenberg R. Scott Williams Jason G. Williams Thomas A. Kunkel Lars C. Pedersen Katarzyna Bebenek |
| author_sort | Andrea M. Kaminski |
| collection | DOAJ |
| description | DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syndrome causing disease mutations. |
| first_indexed | 2024-12-14T16:23:38Z |
| format | Article |
| id | doaj.art-90b1969015cf4216b1c79319d6b65acc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:23:38Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-90b1969015cf4216b1c79319d6b65acc2022-12-21T22:54:44ZengNature PortfolioNature Communications2041-17232018-07-019111210.1038/s41467-018-05024-8Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysisAndrea M. Kaminski0Percy P. Tumbale1Matthew J. Schellenberg2R. Scott Williams3Jason G. Williams4Thomas A. Kunkel5Lars C. Pedersen6Katarzyna Bebenek7Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthEpigenetics & Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthDNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syndrome causing disease mutations.https://doi.org/10.1038/s41467-018-05024-8 |
| spellingShingle | Andrea M. Kaminski Percy P. Tumbale Matthew J. Schellenberg R. Scott Williams Jason G. Williams Thomas A. Kunkel Lars C. Pedersen Katarzyna Bebenek Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis Nature Communications |
| title | Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis |
| title_full | Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis |
| title_fullStr | Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis |
| title_full_unstemmed | Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis |
| title_short | Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis |
| title_sort | structures of dna bound human ligase iv catalytic core reveal insights into substrate binding and catalysis |
| url | https://doi.org/10.1038/s41467-018-05024-8 |
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