The Expression of RAAS Key Receptors, <i>Agtr2</i> and <i>Bdkrb1</i>, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome

The Expression of RAAS Key Receptors, <i>Agtr2</i> and <i>Bdkrb1</i>, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome

Wolfram syndrome (WS) 1 is a rare monogenic neurodegenerative disorder caused by mutations in the gene encoding WFS1. Knowledge of the pathophysiology of WS is incomplete and to date, there is no treatment available. Here, we describe early deviations in the renin-angiotensin-aldosterone system (RAA...

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Bibliographic Details
Main Authors: Marite Punapart, Kadri Seppa, Toomas Jagomäe, Mailis Liiv, Riin Reimets, Silvia Kirillov, Allen Kaasik, Lieve Moons, Lies De Groef, Anton Terasmaa, Eero Vasar, Mario Plaas
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Genes
Subjects:
Wolfram syndrome
<i>Wfs1</i>
<i>Wfs1</i> knock-out
liraglutide
valproic acid
RAAS
Online Access:https://www.mdpi.com/2073-4425/12/11/1717

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https://www.mdpi.com/2073-4425/12/11/1717

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