Investigating the Effect of Surface Hydrophilicity on the Destiny of PLGA-Poloxamer Nanoparticles in an In Vivo Animal Model

Investigating the Effect of Surface Hydrophilicity on the Destiny of PLGA-Poloxamer Nanoparticles in an In Vivo Animal Model

This study aimed to examine the impact of different surface properties of poly(lactic-co-glycolic) acid (PLGA) nanoparticles (P NPs) and PLGA-Poloxamer nanoparticles (PP NPs) on their in vivo biodistribution. For this purpose, NPs were formulated via nanoprecipitation and loaded with diphenylhexatri...

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Bibliographic Details
Main Authors: Teresa Silvestri, Lucia Grumetto, Ilaria Neri, Maria De Falco, Sossio Fabio Graziano, Sara Damiano, Daniela Giaquinto, Lucianna Maruccio, Paolo de Girolamo, Fabrizio Villapiano, Roberto Ciarcia, Laura Mayol, Marco Biondi
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
nanoparticles (NPs)
in vivo
biodistribution
poly(lactic-co-glycolic) acid (PLGA)
poloxamers
polymeric blend
Online Access:https://www.mdpi.com/1422-0067/24/19/14523

Internet

https://www.mdpi.com/1422-0067/24/19/14523

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