Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

<p>Abstract</p> <p>Background</p> <p>BRCA1 (breast cancer 1, early onset) missense mutations have been detected in familial breast and ovarian cancers, but the role of these variants in cancer predisposition is often difficult to ascertain. In this work, the molecular m...

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Bibliographic Details
Main Authors: Iofrida Caterina, Melissari Erika, Mariotti Veronica, Guglielmi Chiara, Guidugli Lucia, Caligo Maria, Pellegrini Silvia
Format: Article
Language:English
Published: BMC 2012-05-01
Series:BMC Cancer
Subjects:
Gene expression
Microarray analysis
Missense mutations
BRCA1 gene
DNA damage
DNA repair
Genomic instability
Cell proliferation
Breast neoplasms
Apoptosis
Online Access:http://www.biomedcentral.com/1471-2407/12/207

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http://www.biomedcentral.com/1471-2407/12/207

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