The Clinical and Molecular Profile of Lung Cancer Patients Harboring the <i>TP53</i> R337H Germline Variant in a Brazilian Cancer Center: The Possible Mechanism of Carcinogenesis

The Clinical and Molecular Profile of Lung Cancer Patients Harboring the <i>TP53</i> R337H Germline Variant in a Brazilian Cancer Center: The Possible Mechanism of Carcinogenesis

In southern and southeastern Brazil, the <i>TP53</i> founder variant c.1010G>A (R337H) has been previously documented with a prevalence of 0.3% within the general population and linked to a heightened incidence of lung adenocarcinomas (LUADs). In the present investigation, we cover cl...

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Bibliographic Details
Main Authors: Carlos D. H. Lopes, Fernanda F. Antonacio, Priscila M. G. Moraes, Paula F. Asprino, Pedro A. F. Galante, Denis L. Jardim, Mariana P. de Macedo, Renata L. Sandoval, Artur Katz, Gilberto de Castro, Maria Isabel Achatz
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
lung cancer
<i>TP53</i> R337H variant
Li-Fraumeni syndrome
lung adenocarcinoma
molecular profiling
particulate matter
Online Access:https://www.mdpi.com/1422-0067/24/20/15035

Internet

https://www.mdpi.com/1422-0067/24/20/15035

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