Molecular mechanism of phosphopeptide neoantigen immunogenicity

Molecular mechanism of phosphopeptide neoantigen immunogenicity

Abstract Altered protein phosphorylation in cancer cells often leads to surface presentation of phosphopeptide neoantigens. However, their role in cancer immunogenicity remains unclear. Here we describe a mechanism by which an HLA-B*0702-specific acute myeloid leukemia phosphoneoantigen, pMLL747–755...

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Bibliographic Details
Main Authors: Yury Patskovsky, Aswin Natarajan, Larysa Patskovska, Samantha Nyovanie, Bishnu Joshi, Benjamin Morin, Christine Brittsan, Olivia Huber, Samuel Gordon, Xavier Michelet, Florian Schmitzberger, Robert B. Stein, Mark A. Findeis, Andy Hurwitz, Marc Van Dijk, Eleni Chantzoura, Alvaro S. Yague, Daniel Pollack Smith, Jennifer S. Buell, Dennis Underwood, Michelle Krogsgaard
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39425-1

Internet

https://doi.org/10.1038/s41467-023-39425-1

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