Features of changes in the expression level of TNFα receptors and the functional response of cell lines upon stimulation with various doses of cytokine

Features of changes in the expression level of TNFα receptors and the functional response of cell lines upon stimulation with various doses of cytokine

TNFa is a pro-inflammatory cytokine that is signaled through type 1 (TNFR1) and type 2 (TNFR2) receptors. TNFR1 normally mediates apoptosis, cell survival, and cytokine secretion, while TNFR2 selectively mediates cell survival and cytokine secretion. But in some cases, when receptors are activated,...

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Bibliographic Details
Main Authors: Yu. A. Lopatnikova, Yu. V. Zhukova, A. A. Alshevskaya, I. A. Obleukhova, F. D. Kireev, I. A. Belomestnova, S. V. Sennikov
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2023-06-01
Series:Медицинская иммунология
Subjects:
tumor necrosis factor alpha
cell lines
tumor necrosis factor receptor 1
tumor necrosis factor receptor 2
apoptosis
receptor expression density
Online Access:https://www.mimmun.ru/mimmun/article/view/2718

Internet

https://www.mimmun.ru/mimmun/article/view/2718

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