Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations

Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations

The mitochondrial ADP/ATP carrier (AAC) exports ATP and imports ADP through alternating between cytosol-open (c-) and matrix-open (m-) states. The salt bridge networks near the matrix side (m-gate) and cytosol side (c-gate) are thought to be crucial for state transitions, yet our knowledge on these...

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Bibliographic Details
Main Authors: Shihao Yao, Boyuan Ma, Qiuzi Yi, Min-Xin Guan, Xiaohui Cang
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
ADP/ATP carrier
mitochondrial carrier family
transporter
molecular dynamics simulation
Online Access:https://www.mdpi.com/1420-3049/27/3/1071

Internet

https://www.mdpi.com/1420-3049/27/3/1071

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