Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs <italic toggle="yes">In Vivo</italic> and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism
ABSTRACT Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to differentiate along the myeloid lineage. In this study, we used an HSPC transplantation model to investigate the possible direct interaction of β-glucan and its receptor (dectin-1) on HSPCs in vivo. P...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2020-06-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00781-20 |