Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods.

Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods.

Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the persistence of a latent viral reservoir in resting CD4+ T cells. This reservoir is a major barrier to cure. Sequencing studies have revealed that the population of proviruses persisting in ART-treated...

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Bibliographic Details
Main Authors: Jennifer A White, Joshua T Kufera, Niklas Bachmann, Weiwei Dai, Francesco R Simonetti, Ciara Armstrong, Jun Lai, Subul Beg, Janet D Siliciano, Robert F Siliciano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010845

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https://doi.org/10.1371/journal.ppat.1010845

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