Inoculum-Based Dosing: A Novel Concept for Combining Time with Concentration-Dependent Antibiotics to Optimize Clinical and Microbiological Outcomes in Severe Gram Negative Sepsis
Certain classes of antibiotics show “concentration dependent” antimicrobial activity; higher concentrations result in increased bacterial killing rates, in contrast to “time dependent antibiotics”, which show antimicrobial activity that depends on the time that antibiotic concentrations remain above...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/11/1581 |