Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry.

Bibliographic Details
Main Authors: Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun, Julian Taylor, Rachel Parker, Lucy M. Kimbley, Serena J. Chee, Emily C. Shaw, Jonathan West, Aiman Alzetani, Edwin Woo, Christian H. Ottensmeier, Matthew J. J. Rose-Zerilli, Gareth J. Thomas
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-35832-6

Internet

https://doi.org/10.1038/s41467-023-35832-6

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