Large domains of heterochromatin direct the formation of short mitotic chromosome loops

Large domains of heterochromatin direct the formation of short mitotic chromosome loops

During mitosis chromosomes reorganise into highly compact, rod-shaped forms, thought to consist of consecutive chromatin loops around a central protein scaffold. Condensin complexes are involved in chromatin compaction, but the contribution of other chromatin proteins, DNA sequence and histone modif...

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Bibliographic Details
Main Authors: Maximilian H Fitz-James, Pin Tong, Alison L Pidoux, Hakan Ozadam, Liyan Yang, Sharon A White, Job Dekker, Robin C Allshire
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
chromosome structure
heterochromatin
condensin
loop extrusion
Online Access:https://elifesciences.org/articles/57212

Internet

https://elifesciences.org/articles/57212

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