Tandem Hock and Friedel–Crafts reactions allowing an expedient synthesis of a cyclolignan-type scaffold

Tandem Hock and Friedel–Crafts reactions allowing an expedient synthesis of a cyclolignan-type scaffold

The Hock cleavage, which is compatible with tandem processes, was applied to the synthesis of 1-aryltetralines through a one-pot transformation from readily available benzyl(prenyl)malonate substrates. After the photooxygenation of the prenyl moiety, the resulting hydroperoxide was directly engaged...

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Bibliographic Details
Main Authors: Viktoria A. Ikonnikova, Cristina Cheibas, Oscar Gayraud, Alexandra E. Bosnidou, Nicolas Casaretto, Gilles Frison, Bastien Nay
Format: Article
Language:English
Published: Beilstein-Institut 2024-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
1-aryltetralines
friedel–crafts reaction
hock rearrangement
oxidative cleavage
tandem reactions
Online Access:https://doi.org/10.3762/bjoc.20.15

Internet

https://doi.org/10.3762/bjoc.20.15

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