Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences

Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences

A single-cell RNA-seq analysis of placental villous tissue provides a deconvolution reference atlas of fetal and maternal placental cell types, and indicates that placental cellular heterogeneity in preeclampsia might contribute to differences in bulk gene expression.

Bibliographic Details
Main Authors: Kyle A. Campbell, Justin A. Colacino, Muraly Puttabyatappa, John F. Dou, Elana R. Elkin, Saher S. Hammoud, Steven E. Domino, Dana C. Dolinoy, Jaclyn M. Goodrich, Rita Loch-Caruso, Vasantha Padmanabhan, Kelly M. Bakulski
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04623-6

Internet

https://doi.org/10.1038/s42003-023-04623-6

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