Polypeptides inhibit HIV-1 replication by interfering viral Vpu-mediated tetherin degradation

Polypeptides inhibit HIV-1 replication by interfering viral Vpu-mediated tetherin degradation

Abstracts: Background: HIV-1 Vpu acts by counteracting the tethering function of tetherin and resulting in the release of HIV-1 virion. Disrupting Vpu-tetherin interactions may provide a promising new target for antiretroviral therapy. Methods: Polypeptides that covered the amino acid sequence on t...

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Bibliographic Details
Main Authors: Shuai Chang, Lifeng Cai, Yongchang Yang, Binlian Sun, Jingyun Li, Jie Liu, Lin Li
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Infectious Medicine
Subjects:
Antiretroviral
HIV-1
Polypeptide
Vpu
Tetherin
Online Access:http://www.sciencedirect.com/science/article/pii/S2772431X23000394

Internet

http://www.sciencedirect.com/science/article/pii/S2772431X23000394

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