A MD Simulation Prediction for Regulation of <i>N</i>-Terminal Modification on Binding of CD47 to CD172a in a Force-Dependent Manner

A MD Simulation Prediction for Regulation of <i>N</i>-Terminal Modification on Binding of CD47 to CD172a in a Force-Dependent Manner

Cancer cells can evade immune surveillance through binding of its transmembrane receptor CD47 to CD172a on myeloid cells. CD47 is recognized as a promising immune checkpoint for cancer immunotherapy inhibiting macrophage phagocytosis. <i>N</i>-terminal post-translated modification (PTM)...

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Bibliographic Details
Main Authors: Yang Zhao, Liping Fang, Pei Guo, Ying Fang, Jianhua Wu
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
CD47
CD172a
post-translated modification
molecular dynamics simulation
structure–function relation
mechano-chemical regulation
Online Access:https://www.mdpi.com/1420-3049/28/10/4224

Internet

https://www.mdpi.com/1420-3049/28/10/4224

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