Loss of Nitric Oxide Induces Fibrogenic Response in Organotypic 3D Co-Culture of Mammary Epithelia and Fibroblasts—An Indicator for Breast Carcinogenesis

Loss of Nitric Oxide Induces Fibrogenic Response in Organotypic 3D Co-Culture of Mammary Epithelia and Fibroblasts—An Indicator for Breast Carcinogenesis

Excessive myofibroblast activation, which leads to dysregulated collagen deposition and the stiffening of the extracellular matrix (ECM), plays pivotal roles in cancer initiation and progression. Cumulative evidence attests to the cancer-causing effects of a number of fibrogenic factors found in the...

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Bibliographic Details
Main Authors: Gang Ren, Xunzhen Zheng, Vandana Sharma, Joshua Letson, Andrea L. Nestor-Kalinoski, Saori Furuta
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
organotypic 3D co-culture
extracellular matrix
mammary gland
fibroblasts
myofibroblasts
desmoplasia
Online Access:https://www.mdpi.com/2072-6694/13/11/2815

Internet

https://www.mdpi.com/2072-6694/13/11/2815

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