<i>BRAF</i> and MEK Targeted Therapies in Pediatric Central Nervous System Tumors

<i>BRAF</i> and MEK Targeted Therapies in Pediatric Central Nervous System Tumors

<i>BRAF</i> is a component of the MAPK and PI3K/AKT/mTOR pathways that play a crucial role in cellular proliferation, differentiation, migration, and angiogenesis. Pediatric central nervous system tumors very often show mutations of the MAPK pathway, as demonstrated by next-generation se...

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Bibliographic Details
Main Authors: Dario Talloa, Silvia Triarico, Pierpaolo Agresti, Stefano Mastrangelo, Giorgio Attinà, Alberto Romano, Palma Maurizi, Antonio Ruggiero
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
central nervous system (CNS) tumors
<i>BRAF</i>
MEK
children
NGS
targeted therapies
Online Access:https://www.mdpi.com/2072-6694/14/17/4264

Internet

https://www.mdpi.com/2072-6694/14/17/4264

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