Thalidomide Prevented and Ameliorated Pathogenesis of Crohn’s Disease in Mice via Regulation of Inflammatory Response and Fibrosis

Thalidomide Prevented and Ameliorated Pathogenesis of Crohn’s Disease in Mice via Regulation of Inflammatory Response and Fibrosis

Crohn’s disease (CD) is a chronic, relapsing form of inflammatory bowel disease, seriously threatening human health. Thalidomide has been used for the treatment of CD. However, the effects and the possible mechanisms of thalidomide on CD are still unclear. Herein, our study demonstrated that thalido...

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Bibliographic Details
Main Authors: Hongjin Chen, Haixia Xu, Lijiao Luo, Lichao Qiao, Yaohui Wang, Minmin Xu, Youran Li, Ping Zhu, Bolin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
Crohn’s disease
thalidomide
fibrosis
animal model
inflammation
mechanism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01486/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01486/full

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