The Critical Role of Hypoxia in the Re-Differentiation of Human Articular Chondrocytes

The Critical Role of Hypoxia in the Re-Differentiation of Human Articular Chondrocytes

The preservation of the chondrogenic phenotype and hypoxia-related physiological microenvironment are major challenges in the 2D culture of primary human chondrocytes. To address this problem, we develop a 3D culture system generating scaffold-free spheroids from human chondrocytes. Our results high...

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Bibliographic Details
Main Authors: Carlos Martinez-Armenta, Carlos Suarez-Ahedo, Anell Olivos-Meza, María C. Camacho-Rea, Laura E. Martínez-Gómez, Guadalupe Elizabeth Jimenez-Gutierrez, Gabriela A. Martínez-Nava, Luis E. Gomez-Quiroz, Carlos Pineda, Alberto López-Reyes
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
chondrocyte
hypoxia
cartilage
re-differentiation
3D cell culture
Online Access:https://www.mdpi.com/2073-4409/11/16/2553

Internet

https://www.mdpi.com/2073-4409/11/16/2553

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