Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

Abstract One of the major hurdles that has hindered the success of chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target off-tumor (OTOT) toxicity due to sharing of the same epitopes on normal tissues. To elevate the safety profile of CAR-T cells, an affinity/avidity fin...

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Bibliographic Details
Main Authors: Yufei Wang, Alicia Buck, Brandon Piel, Luann Zerefa, Nithyassree Murugan, Christian D. Coherd, Andras G. Miklosi, Haraman Johal, Ricardo Nunes Bastos, Kun Huang, Miriam Ficial, Yasmin Nabil Laimon, Sabina Signoretti, Zhou Zhong, Song-My Hoang, Gabriella M. Kastrunes, Marion Grimaud, Atef Fayed, Hsien-Chi Yuan, Quang-De Nguyen, Tran Thai, Elena V. Ivanova, Cloud P. Paweletz, Ming-Ru Wu, Toni K. Choueiri, Jon O. Wee, Gordon J. Freeman, David A. Barbie, Wayne A. Marasco
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Molecular Cancer
Subjects:
Chimeric antigen receptor (CAR) T
Affinity/avidity fine-tuned
Clear cell renal cell carcinoma (ccRCC)
Carbonic anhydrase IX (CAIX)
Direct stochastic optical reconstruction microscopy (dSTORM)
On-target off-tumor (OTOT) toxicity
Online Access:https://doi.org/10.1186/s12943-024-01952-w

Internet

https://doi.org/10.1186/s12943-024-01952-w

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