FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells

FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells

Abstract Background The maintenance of genome stability in primordial germ cells (PGCs) is crucial for the faithful transmission of genetic information and the establishment of reproductive reserve. Numerous studies in recent decades have linked the Fanconi anemia (FA) pathway with fertility, partic...

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Bibliographic Details
Main Authors: Weiwei Xu, Yajuan Yang, Yongze Yu, Canxin Wen, Simin Zhao, Lili Cao, Shidou Zhao, Yingying Qin, Zi-Jiang Chen
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Biology
Subjects:
Primordial germ cells
FAAP100
Genome stability
Transcription-replication conflicts
R-loop
Online Access:https://doi.org/10.1186/s12915-023-01676-1

Internet

https://doi.org/10.1186/s12915-023-01676-1

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