A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency

A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency

Methyl CpG binding protein 2 (MeCP2) is a DNA methylation reader protein. Mutations in MeCP2 are the major cause of Rett syndrome (RTT). Increasing evidence has shown that dysregulated immunity and chronic subclinical inflammation are linked to MeCP2 deficiency and contribute to RTT development and...

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Bibliographic Details
Main Authors: Huiping Li, Meixin Hu, Zhuxi Huang, Yi Wang, Ying Xu, Jingxin Deng, Ming Zhu, Weijun Feng, Xiu Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
methyl CpG binding protein 2
Rett syndrome
meningeal immunity
mouse model
central nervous system
single-cell analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1056447/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1056447/full

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