Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and colonize humanized mice

Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and colonize humanized mice

ABSTRACT Salmonella enterica serovar Typhi (S. Typhi) is a human-restricted pathogen that replicates in macrophages. In this study, we investigated the roles of the S. Typhi type 3 secretion systems (T3SSs) encoded on Salmonella pathogenicity islands (SPI)-1 (T3SS-1) and SPI-2 (T3SS-2) during human...

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Bibliographic Details
Main Authors: Meagan Hamblin, Ruth Schade, Ramya Narasimhan, Denise M. Monack
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
typhoidal
T3SS-1
T3SS-2
typhoid fever
pathogenesis
Online Access:https://journals.asm.org/doi/10.1128/mbio.01137-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01137-23

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