Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease

Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease

Abstract Background Celiac disease (CD) is an autoimmune disorder triggered by gluten consumption. Almost all CD patients possess human leukocyte antigen (HLA) DQ2/DQ8 haplotypes; however, only a small subset of individuals carrying these alleles develop CD, indicating the role of environmental fact...

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Bibliographic Details
Main Authors: Khyati Girdhar, Yusuf Dogus Dogru, Qian Huang, Yi Yang, Vladimir Tolstikov, Amol Raisingani, Martina Chrudinova, Jaewon Oh, Kristina Kelley, Jonas F. Ludvigsson, Michael A. Kiebish, Noah W. Palm, Johnny Ludvigsson, Emrah Altindis
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Microbiome
Subjects:
Celiac disease
Gut microbiota
IgA sequencing
Metabolites
Cytokines
Taurodeoxycholic acid
Online Access:https://doi.org/10.1186/s40168-022-01429-2

Internet

https://doi.org/10.1186/s40168-022-01429-2

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