A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry

A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry

Herein, we report on the solvent-free synthesis of 2-aminothiophenes via the Gewald reaction. Utilizing high speed ball milling conditions, we discovered the Gewald reaction can be catalytic in base, and conducted under aerobic conditions. Using thermal heat in tandem with the mixer/mill significant...

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Bibliographic Details
Main Authors: William C. Shearouse, Maxwell Z. Shumba, James Mack
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Applied Sciences
Subjects:
Gewald
solvent-free
ball milling
green chemistry
multicomponent reaction
Online Access:http://www.mdpi.com/2076-3417/4/2/171

Internet

http://www.mdpi.com/2076-3417/4/2/171

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