A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry
Herein, we report on the solvent-free synthesis of 2-aminothiophenes via the Gewald reaction. Utilizing high speed ball milling conditions, we discovered the Gewald reaction can be catalytic in base, and conducted under aerobic conditions. Using thermal heat in tandem with the mixer/mill significant...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-04-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3417/4/2/171 |
| _version_ | 1817976197957550080 |
|---|---|
| author | William C. Shearouse Maxwell Z. Shumba James Mack |
| author_facet | William C. Shearouse Maxwell Z. Shumba James Mack |
| author_sort | William C. Shearouse |
| collection | DOAJ |
| description | Herein, we report on the solvent-free synthesis of 2-aminothiophenes via the Gewald reaction. Utilizing high speed ball milling conditions, we discovered the Gewald reaction can be catalytic in base, and conducted under aerobic conditions. Using thermal heat in tandem with the mixer/mill significantly increases the rate of reaction. |
| first_indexed | 2024-04-13T21:59:22Z |
| format | Article |
| id | doaj.art-90eeb737737a4b33baf03551b1767e51 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-13T21:59:22Z |
| publishDate | 2014-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-90eeb737737a4b33baf03551b1767e512022-12-22T02:28:08ZengMDPI AGApplied Sciences2076-34172014-04-014217117910.3390/app4020171app4020171A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via MechanochemistryWilliam C. Shearouse0Maxwell Z. Shumba1James Mack2University of Cincinnati, Cincinnati, OH 45221-0172, USAUniversity of Cincinnati, Cincinnati, OH 45221-0172, USAUniversity of Cincinnati, Cincinnati, OH 45221-0172, USAHerein, we report on the solvent-free synthesis of 2-aminothiophenes via the Gewald reaction. Utilizing high speed ball milling conditions, we discovered the Gewald reaction can be catalytic in base, and conducted under aerobic conditions. Using thermal heat in tandem with the mixer/mill significantly increases the rate of reaction.http://www.mdpi.com/2076-3417/4/2/171Gewaldsolvent-freeball millinggreen chemistrymulticomponent reaction |
| spellingShingle | William C. Shearouse Maxwell Z. Shumba James Mack A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry Applied Sciences Gewald solvent-free ball milling green chemistry multicomponent reaction |
| title | A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry |
| title_full | A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry |
| title_fullStr | A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry |
| title_full_unstemmed | A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry |
| title_short | A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry |
| title_sort | solvent free one step one pot gewald reaction for alkyl aryl ketones via mechanochemistry |
| topic | Gewald solvent-free ball milling green chemistry multicomponent reaction |
| url | http://www.mdpi.com/2076-3417/4/2/171 |
| work_keys_str_mv | AT williamcshearouse asolventfreeonesteponepotgewaldreactionforalkylarylketonesviamechanochemistry AT maxwellzshumba asolventfreeonesteponepotgewaldreactionforalkylarylketonesviamechanochemistry AT jamesmack asolventfreeonesteponepotgewaldreactionforalkylarylketonesviamechanochemistry AT williamcshearouse solventfreeonesteponepotgewaldreactionforalkylarylketonesviamechanochemistry AT maxwellzshumba solventfreeonesteponepotgewaldreactionforalkylarylketonesviamechanochemistry AT jamesmack solventfreeonesteponepotgewaldreactionforalkylarylketonesviamechanochemistry |