GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas

GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas

Abstract Background Bioenergetic characterisation of malignant tissues revealed that different tumour cells can catabolise multiple substrates as salvage pathways, in response to metabolic stress. Altered metabolism in gliomas has received a lot of attention, especially in relation to IDH mutations,...

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Main Authors: Zoltán Hujber, Gergő Horváth, Gábor Petővári, Ildikó Krencz, Titanilla Dankó, Katalin Mészáros, Hajnalka Rajnai, Norbert Szoboszlai, William P. J. Leenders, András Jeney, László Tretter, Anna Sebestyén
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioma
Bioenergetics
IDH1 mutation
2-hydroxyglutarate
Glutamine
GABA
Online Access:http://link.springer.com/article/10.1186/s13046-018-0946-5

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http://link.springer.com/article/10.1186/s13046-018-0946-5

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