Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa
TCRαβ+CD8αα+ intraepithelial lymphocytes (IELs) are abundant in gastrointestinal (GI) tract and play an important role in regulation of mucosal immunity and tolerance in the gut. However, it is unknown whether TCRαβ+CD8αα+ IELs exist in the oral mucosa and if yes, what controls their development. We...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01702/full |
| _version_ | 1828531787897241600 |
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| author | Ruiqing Wu Ruiqing Wu Dunfang Zhang Peter Zanvit Wenwen Jin Hao Wang Hao Wang WanJun Chen |
| author_facet | Ruiqing Wu Ruiqing Wu Dunfang Zhang Peter Zanvit Wenwen Jin Hao Wang Hao Wang WanJun Chen |
| author_sort | Ruiqing Wu |
| collection | DOAJ |
| description | TCRαβ+CD8αα+ intraepithelial lymphocytes (IELs) are abundant in gastrointestinal (GI) tract and play an important role in regulation of mucosal immunity and tolerance in the gut. However, it is unknown whether TCRαβ+CD8αα+ IELs exist in the oral mucosa and if yes, what controls their development. We here identified and characterized TCRαβ+CD8αα+ IELs from the murine oral mucosa. We showed that the number and function of TCRαβ+CD8αα+ IELs were regulated by TGF-β. We further revealed that oral TCRαβ+CD8αα+ IELs could be altered under systemic inflammatory conditions and by antibiotic treatment at the neonatal age of the mice. Our findings have revealed a previously unrecognized population of oral IELs that may regulate oral mucosal immune responses. |
| first_indexed | 2024-12-11T22:42:56Z |
| format | Article |
| id | doaj.art-90f49bc040eb4c06a8417673282d3e66 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T22:42:56Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-90f49bc040eb4c06a8417673282d3e662022-12-22T00:47:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01702519938Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral MucosaRuiqing Wu0Ruiqing Wu1Dunfang Zhang2Peter Zanvit3Wenwen Jin4Hao Wang5Hao Wang6WanJun Chen7Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United StatesBeijing Tiantan Hospital, Capital Medical University, Beijing, ChinaMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United StatesMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United StatesMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United StatesMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United StatesBeijing Tiantan Hospital, Capital Medical University, Beijing, ChinaMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United StatesTCRαβ+CD8αα+ intraepithelial lymphocytes (IELs) are abundant in gastrointestinal (GI) tract and play an important role in regulation of mucosal immunity and tolerance in the gut. However, it is unknown whether TCRαβ+CD8αα+ IELs exist in the oral mucosa and if yes, what controls their development. We here identified and characterized TCRαβ+CD8αα+ IELs from the murine oral mucosa. We showed that the number and function of TCRαβ+CD8αα+ IELs were regulated by TGF-β. We further revealed that oral TCRαβ+CD8αα+ IELs could be altered under systemic inflammatory conditions and by antibiotic treatment at the neonatal age of the mice. Our findings have revealed a previously unrecognized population of oral IELs that may regulate oral mucosal immune responses.https://www.frontiersin.org/article/10.3389/fimmu.2020.01702/fullTCRαβ+CD8αα+intraepithelial lymphocytesunconventional immune cellsTGF-βoral mucosa |
| spellingShingle | Ruiqing Wu Ruiqing Wu Dunfang Zhang Peter Zanvit Wenwen Jin Hao Wang Hao Wang WanJun Chen Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa Frontiers in Immunology TCRαβ+CD8αα+ intraepithelial lymphocytes unconventional immune cells TGF-β oral mucosa |
| title | Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa |
| title_full | Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa |
| title_fullStr | Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa |
| title_full_unstemmed | Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa |
| title_short | Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa |
| title_sort | identification and regulation of tcrαβ cd8αα intraepithelial lymphocytes in murine oral mucosa |
| topic | TCRαβ+CD8αα+ intraepithelial lymphocytes unconventional immune cells TGF-β oral mucosa |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01702/full |
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