Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFβ2 Induced Primary Open Angle Glaucoma

Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFβ2 Induced Primary Open Angle Glaucoma

Elevated intraocular pressure (IOP) is a major risk factor in developing primary open angle glaucoma (POAG), which is the most common form of glaucoma. Transforming growth factor-beta 2 (TGFβ2) is a pro-fibrotic cytokine that plays an important role in POAG pathogenesis. TGFβ2 induced extracellular...

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Bibliographic Details
Main Authors: Ramesh B. Kasetti, Prabhavathi Maddineni, Bindu Kodati, Bhavani Nagarajan, Sam Yacoub
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
astragaloside IV
trabecular meshwork
TGFβ2
myocilin
ECM
MMP
Online Access:https://www.mdpi.com/1422-0067/22/22/12508

Internet

https://www.mdpi.com/1422-0067/22/22/12508

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