Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation

Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation

Hypochlorous acid (HOCl) is an essential signal molecule in cancer cells. Activated GRP78 ATPase by a HOCl probe named ZBM-H inhibits lung cancer cell growth. However, the role and underlying mechanism of GRP78 ATPase in lung cancer cell migration have not been established. Here, we reported that ac...

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Bibliographic Details
Main Authors: Junya Ning, Xiaoling Cui, Nan Li, Na Li, Baoxiang Zhao, Junying Miao, Zhaomin Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Cell Adhesion & Migration
Subjects:
Integrin β4
cell migration
glucose-regulated protein 78
hypochlorous acid probe
lung cancer cells
Online Access:https://www.tandfonline.com/doi/10.1080/19336918.2022.2130415

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https://www.tandfonline.com/doi/10.1080/19336918.2022.2130415

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