Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab

Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab

Interspecies translation of monoclonal antibodies (mAbs) pharmacokinetics (PK) in presence of target-mediated drug disposition (TMDD) is particularly challenging. Incorporation of TMDD in physiologically based PK (PBPK) modeling is recent and needs to be consolidated and generalized to provide bette...

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Bibliographic Details
Main Authors: Blaise Pasquiers, Salih Benamara, Mathieu Felices, David Ternant, Xavier Declèves, Alicja Puszkiel
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
translational PBPK
monoclonal antibody
bevacizumab
TMDD
Online Access:https://www.mdpi.com/1999-4923/15/8/2129

Internet

https://www.mdpi.com/1999-4923/15/8/2129

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